Willem Aantjes (born 1923), Dutch politician
Willem Adelaar (born 1948), Dutch linguist
Willem Andriessen (1887–1964), Dutch pianist and composer
Willem Arondeus (1894–1943), Dutch artist and author
Willem Barentsz (~1550–1597), Dutch navigator and explorer
Willem Bilderdijk (1756–1831), Dutch poet
Willem Blaeu (1571–1638), Dutch cartographer, publisher
Willem Boy (1520–1592), Flemish painter, sculptor, and architect
Willem Breuker (born 1944), Dutch jazz bandleader, composer, and musician
Willem Brouwer (born 1963), Dutch football (soccer) player
Willem Buiter (born 1949), Dutch economist
Willem Buytewech (1591–1624), Dutch painter, draughtsman, and etcher
Willem Claeszoon Heda (~1594–1680), Dutch artist
Willem Cornelisz Schouten (~1567–1625), Dutch navigator
Willem Dafoe (born 1955), American actor
Willem de Kooning (1904 –1997), Dutch expressionist painter
Willem de Rooij (born 1969), Dutch artist
Willem de Sitter (1872–1934), Dutch mathematician, physicist and astronomer
Willem de Vlamingh (~1640–1698), Dutch sea-captain and explorer
Willem Drees (1886–1988), Dutch politician
Willem Drost (1633–1659), Dutch Golden Age painter and printmaker
Willem Einthoven (1860–1927), Dutch physiologist, inventor of the electrocardiogram
Willem Elsschot (1882–1960), Flemish writer and poet
Willem Endstra (1953–2004), Dutch real estate trader
Willem Frederik Hermans (1921–1995), Dutch author
Willem Gravesande (1688–1742), Dutch philosopher and mathematician
Willem Hondt (~1598–1652), Dutch engraver, cartographer and painter
Willem Hubert van Blijenburgh (1881–1936), Dutch Olympic fencer
Willem I (1772–1843), King of the Netherlands
Willem II (1792–1849), King of the Netherlands
Willem III (1817–1890), King of the Netherlands
Willem Janssen (born 1984), Dutch footballer
Willem Janszoon (~1570–1630), Dutch navigator and colonial governor
Willem Johan Kolff (1911–2009), inventor of the artificial kidney
Willem Kalf (1619–1693), Dutch Golden Age painter, art dealer, and appraiser
Willem Kes (1856–1934), Dutch conductor and violinist
Willem Kieft (1597–1647), Dutch merchant and director-general of New Netherland
Willem Kloos (1859–1938), Dutch poet and literary critic
Willem Konjore (born 1945), Namibian politician
Willem Luyten (1899–1994), Dutch-American astronomer
Willem Maris (1844–1910), Dutch landscape painter
Willem Meijer (1923–2003), Dutch botanist and plant collector
Willem Mengelberg (1871–1951), Dutch conductor
Willem of the Netherlands (1840–1879), Dutch prince
Willem Oltmans (1925–2004), Dutch journalist
Willem Pijper (1894–1947), Dutch composer, music critic, and music teacher
Willem Roelofs (1822–1897), Dutch painter, lithographer and draughtsman
Willem Sandberg (1897–1984), Dutch typographer and museum curator
Willem Sassen (1918–2002), Dutch Nazi collaborator, Waffen-SS officer and journalist
Willem Siebenhaar (1863–1936), Dutch-Australian social activist and writer
Willem Surenhuis (~1664–1729), Dutch Christian scholar
Willem Usselincx (1567–1647), Flemish merchant, investor and diplomat
Willem van Aelst (1627–1683), Dutch still-life artist
Willem Van Biljon (born 1961), South African entrepreneur and technologist
Willem van de Velde the Elder (~1611–1693), Dutch painter
Willem van de Velde the Younger (1633–1707), Dutch painter
Willem van Hanegem (born 1944), Dutch football player and coach
Willem van Mieris (1662–1747), Dutch painter
Willem van Otterloo (1907–1978), Dutch conductor, cellist and composer
Willem Verhulst (1625–†), the second director of the Dutch West India Company
Willem Verstegen (~1612–1659), Dutch merchant
Willem Willink (1750–1841), Dutch merchant
Willem Wilmink (1936–2003), Dutch poet and writer
Willem Wissing (1656–1687), Dutch portrait artist
Willem Witsen (1860–1923), Dutch painter and photographer